Survival Analysis with nlmixr2

Introduction Survival or time-to-event (TTE) analysis models when something happens, not just whether it happens. The endpoint might be time to tumour progression, time to an adverse event, or time to treatment discontinuation, for instance. In this post we’ll illustrate how to fit parametric TTE models in nlmixr2 using its custom log-likelihood interface. For the purposes of this post, we’re going to simulate a two-arm randomised trial from a known Gompertz model, then recover the parameters with nlmixr2.